癌变·畸变·突变 ›› 2004, Vol. 16 ›› Issue (1): 43-45.doi: 10.3969/j.issn.1004-616x.2004.01.013

• 研究简报 • 上一篇    下一篇

PS8812多糖及其硒多糖抗诱变试验

张全新;聂木海   

  1. 广州市疾病预防控制中心毒理科,广东　广州　510080
  • 收稿日期:2003-03-03 修回日期:2003-04-30 出版日期:2004-01-30 发布日期:2004-01-30
  • 通讯作者: 张全新

Anti-mutagenicity test of PS8812 Polysaccharides and its Selenium Polysaccharides

ZHANG Quan-xin;NIE Mu-hai   

  1. Department of Toxicology, Guangzhou Center for Diseases Prevention and control,Guangzhou 510080 , China
  • Received:2003-03-03 Revised:2003-04-30 Online:2004-01-30 Published:2004-01-30
  • Contact: ZHANG Quan-xin

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摘要： 背景与目的：探讨PS8812多糖及其硒多糖的抗诱变作用。材料与方法：采用Ames试验、小鼠骨髓微核及小鼠精子畸形抗突变试验。结果：多糖和硒多糖对鼠伤寒沙门氏菌突变菌株TA98 及TA100 的回复突变有明显抑制作用，最高抑制率分别为65.39 ％和73.21 ％；多糖和硒多糖也能显著降低环磷酰胺诱导的微核率和精子畸形率，微核抑制率为40.24 ％～60.37 ％，精子畸形抑制率为38.92 ％～62.36 ％。结论：PS8812多糖及其硒多糖均有明显的抗诱变作用。

关键词: 多糖, 硒多糖, 抗诱变性

Abstract: BACKGROUND＆AIM: To study the antimutagenic effect of PS8812 Polysaccharides (PSP) and its Selenium Polysaccharides(PSSP).MATERIAL AND METHODS: The Ames test,mouse marrow micronucleus test and mouse sperm malformation test were used. RESULTS: PSP and PSSP both could evidently inhibit the reverse mutation on Salmonella thphimurium strains TA98 and TA100 with and without S9 mix.The rates of maximum inhibition were 65.39 ％ and 73.21 ％ respectively.The frequencies of micronucleus and abnormal sperms induced by cyclophosphamide (CP)were reduced significantly by PSP and PSSP.The inhibitory rate of micronucleus was between 40.24 ％ and 60.37 ％; the inhibitory rate of abnormal sperms was between 38.92 ％ and 62.36 ％.CONCLUSION: PSP and PSSP have significant antimutagenic effect.

Key words: polysa ccharides, selenium polysaccharides, ant- imutagenicity

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